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Maximizing the Potential of Bevacizumab in Cancer Treatment

^a Department of Medicine, University of California, San Francisco, California, USA; ^b Memorial Sloan-Kettering Cancer Center, New York, New York, USA

Correspondence: Emily Bergsland, M.D., Department of Medicine, University of California, San Francisco, 1600 Divisidero Street, 4th Floor, San Francisco, California 94115, USA. Telephone: 415-353-9888; Fax: 415-353-9959; e-mail: emilyb{at}medicine.ucsf.edu

Promising results have been obtained with bevacizumab (Avestin^TM; Genentech, Inc.; South San Francisco, CA) in clinical trials in patients with a range of solid tumors; however, to maximize the potential of this agent, further research is needed to clarify a number of important issues. These include the optimization of bevacizumab dosage and schedule of administration, the potential value of this agent in combination with other treatment modalities like chemotherapy and radiation, the management of toxicities, and the selection of patients most likely to benefit from treatment. Intriguing results from two recent phase III trials highlight the need for a better understanding of the best ways to incorporate bevacizumab into clinical practice. Ultimately, maximizing the potential value of this agent may require a more thorough understanding of bevacizumab’s mechanism of action and the pathways mediating resistance.

Key Words. Solid tumors • Bevacizumab • Chemotherapy • Clinical trials

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